Các yếu tố ảnh hưởng đến quá trình tổng hợp 2 methyl - 5 nitroimidazole=Factors affecting the synthesis of 2 methyl

Các yếu tố ảnh hưởng đến quá trình tổng hợp 2 methyl - 5 nitroimidazole=Factors affecting the synthesis of 2 methyl - 5 nitroimidazole

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Tác giả: Văn Huỳnh Lê

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Khoa học và Công nghệ Đại học Thành Đông, 2024

Mô tả vật lý: tr.1-8

Bộ sưu tập: Báo, Tạp chí

ID: 253374

Thêm vào giỏ

The precursor 2-Methyl-5-nitroimidazole is used to synthesize the antibiotic Metronidazole used to treat bacterial infections. The process of synthesizing 2-Methyl-5-nitroimidazole gave the optimal parameters for the nitrification reaction of 2-methyl-1H-imidazole to produce 2-methyl-5-nitroimidazole products as follows: The molar ratio of 2-methyl-1H-imidazole to the volume of HNO3 acid is 1mol / 125ml
The reaction temperature is 140 – 150oC
The pH of the reaction medium is 5 – 6
The efficiency is 98%. The crystals are pale yellow and have a melting point at 250 – 252oC
This article is the result of research on synthesis of 2-Methyl-5-nitroimidazole precursor and factors affecting the synthesis. The research results are the scientific basis for application to the production technology process, contributing to solving the problem of self-reliance in pharmaceutical raw materials in Vietnam.Tiền chất 2-Methyl-5-nitroimidazole được sử dụng để tổng hợp thuốc kháng sinh Metronidazole dùng để điều trị các bệnh nhiễm khuẩn. Quá trình nghiên cứu tổng hợp 2-Methyl-5-nitroimidazole đã đưa ra được các thông số tối ưu cho phản ứng nitro hóa 2-methyl-1H-imidazole để tạo ra sản phẩm 2-methyl-5-nitroimidazole như sau: Tỷ lệ số mol 2-methyl-1H-imidazole với thể tích acid HNO3 là 1mol / 125ml
Nhiệt độ của phản ứng là 140 – 150C
pH của môi trường phản ứng là 5 – 6. Hiệu suất đạt 98%. Tinh thể có màu vàng nhạt và có điểm chảy ở 250 – 252C. Bài bào này là kết quả nghiên cứu tổng hợp tiền chất 2-Methyl-5-nitroimidazole và các yếu tố ảnh hưởng đến quá trình tổng hợp. Kết quả nghiên cứu là cơ sở khoa học cho việc ứng dụng vào các quá trình công nghệ sản xuất, góp phần giải quyết vấn đề tự chủ nguồn nguyên liệu dược tại Việt Nam.

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