Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids.

• Tác giả: Emmie de Wit, Meaghan Flagg, Tessa R Lutterman, Johan A Ortiz-Morales, Brandi N Williamson
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.5262 Astrology
• Thông tin xuất bản: United States : Emerging infectious diseases , 2025
• Bộ sưu tập: NCBI
• ID: 253572

Tóm tắt

We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of those viruses.