This study aimed to use a new protein complex of Pennisetin (Pen) a non gluten protein of pearl millet and casein (Cas), for curcumin (Cur) extract encapsulation using simple or complex coacervation. The potential improvement of Cur antioxidant activities and α-amylase inhibition after encapsulation was explored. Complex microparticles of Pen and Cas with various ratios exhibited average diameters ranging from 1.95 ± 0.32 to 4.66 ± 0.99 μm, whereas the Cur loaded microparticles had average diameters ranging from 2.50 ± 0.89 to 5.27 ± 1.17 μm. FTIR analysis of Cur loaded microparticles showed the presence of specific peaks at 3757, 1754, 1157 and 856 cm