Anacardic acid (AA) is a phenolic lipid extracted from cashew nutshell liquid that has antitumor activity. Given the high hydrophobicity of this compound and aiming to create efficient vehicle for its administration in aqueous systems, the objective of the present work was to develop a microcapsule (MCAA) by spray dryer technique, based on the polysaccharide sodium hyaluronate (SH), containing AA as its core, encapsulated from nanoemulsion. The Encapsulation Efficiency of MCAA presented a value equal to 95.06 ± 1.22 %. In vitro release kinetic study showed a pH-responsive release, with greater release of AA from MCAA at pH 6.8 and 7.4 and almost none at pH 4.5, which prevents its delivery to the cellular lysosome. Tests on zebrafish did not show acute toxicity within 96 h or change in locomotor activity. The IC