QM/MM study reveals novel mechanism of KRAS and KRAS

• Tác giả: Qin Li, Huanxiang Liu, Xiaomeng Liu, Qin Ouyang, Jiayue Qiu, Yanan Tian, Henry H Y Tong, Xiao Yan, Xiaojun Yao, Lei Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 625.79 Ice crossings, traffic control equipment, protective roadside barriers
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 253852

Tóm tắt

As a crucial drug target, KRAS can regulate most cellular processes involving guanosine triphosphate (GTP) hydrolysis. However, the mechanism of GTP hydrolysis has remained controversial over the past decades. Here, several different GTP hydrolysis mechanisms catalyzed by wild-type KRAS (WT-KRAS) and KRAS