Synthesis of harmaline N-9 derivatives and investigation of in vitro anticancer activity.

• Tác giả: Heng Chen, Jinling Ge, Shuqi Li, Hao Liu, Yonggang Liu, Yongjian Liu, Shaojun Yu
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Bioorganic & medicinal chemistry letters , 2025
• Bộ sưu tập: NCBI
• ID: 253951

Tóm tắt

Harmaline as a natural compound possessed a wide range of pharmacological activities. In this study, 22 novel harmaline-based derivatives were synthesized and screened for in vitro anti-proliferation activity against three cancer cell lines, HCT116, MCF7, and MGC803. The modification site was at the position N-9 of harmaline. The 24-hour IC