Diabetic wounds present a considerable challenge in modern medicine due to their prolonged healing process, driven by sustained inflammation and impaired vascular regeneration. This study introduces a novel hydrogel network through osmosis, utilizing hyaluronic acid (HA) and phytic acid (PA) for their anti-inflammatory and antioxidant properties, respectively. By incorporating recombinant Human Amelogenin (rhAM), known for its angiogenic potential, we aimed to develop the HA-PA-rhAM hydrogel to enhance wound healing in diabetic rats. Our results indicate that this hydrogel has excellent mechanical properties, stability, electrical conductivity, and effective adaptation to irregular wound shapes. In vitro cellular assays demonstrated the hydrogel has an excellent biosafety profile, pro-cell migration, and pro-angiogenic capacity, and the diabetic rat full-thickness wound model further indicated the hydrogel's capacity to promote wound repair, by down-regulating inflammatory factors, promoting the transition of M1-type macrophages to M2-type, and up-regulating the expression of angiogenic markers. In summary, this functional hydrogel has a simple and efficient synthetic pathway and easy clinical translation, making it highly promising for treating chronic diabetic wounds.