Structural conservation and functional role of TfpY-like proteins in type IV pilus assembly.

• Tác giả: Lori L Burrows, Isabelle Chan, Hanjeong Harvey, Ikram Qaderi
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of bacteriology , 2025
• Bộ sưu tập: NCBI
• ID: 254019

Tóm tắt

UNLABELLED: Type IV pili (T4P) are important virulence factors that allow bacteria to adhere to and rapidly colonize their hosts. T4P are primarily composed of major pilins that undergo cycles of extension and retraction and minor pilins that initiate pilus assembly. Bacteriophages use T4P as receptors and exploit pilus dynamics to infect their hosts. Some bacteria encode pilin accessory proteins that post-translationally glycosylate major pilins to evade phage binding. TfpY is an accessory protein of unknown function that is widespread and structurally conserved among T4P-expressing bacteria. Here, we use IMPORTANCE: Type IV pili are surface filaments that enable versatile pathogens, like