Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation.

• Tác giả: Liangyi Chen, Junbao Du, Bin Geng, Yaqian Huang, Hongfang Jin, Xin Liu, Chaoshu Tang, Xinjing Tang, Xiaoyu Tian, Yanan Zhang, Shiqun Zhao, Dan Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.48346 Journalism
• Thông tin xuất bản: Netherlands : Redox biology , 2025
• Bộ sưu tập: NCBI
• ID: 254068

Tóm tắt

BACKGROUND: The binding of endothelin-1 (ET-1) to endothelin type A receptor (ETAR) performs a critical action in pulmonary arterial smooth muscle cell (PASMC) proliferation leading to pulmonary vascular structural remodeling. More evidence showed that cystathionine γ-lyase (CSE)-catalyzed endogenous hydrogen sulfide (H METHODS AND RESULTS: Both live cell imaging and ligand-receptor assays revealed that H CONCLUSION: Endogenous H