Na

• Tác giả: Chunyang Cao, Wenxian Lan, Zhijun Liu, Guoqing Niu, Hongjuan Xue, Shaowen Yin
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.756 Relational databases
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 254090
• Chủ đề: 1. Na; 2. Proto; 3. Oncogene

Tóm tắt

Proto-oncogene RET is overexpressed in many cancers, and its expression level is positively related to the size and malignancy of the tumors. Effective inhibition of its overexpression can be used to potentially treat cancers. A guanine-rich GC-boxes (I-V) sequence in its promoter region folds into noncanonical G-quadruplex (G4) DNA structures, negatively regulating its expression by interactions with small molecules. Previously, we reported that RET20T in GC-boxes II-V formed parallel G4 only at low concentrations of K