Free radical synthesis of succinic anhydride grafted poly(lactic acid) porous templates for sustained drug delivery in the buffer media.

• Tác giả: Y Emre Bulbul, Aysegul Uygun Oksuz, Ammara Rafique, Zulfiqar Ali Raza
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 254136

Tóm tắt

Poly(lactic) (PLA) is a biodegradable material obtained from renewable resources and is recognized as a safe biopolymer by the Food and Drug Administration. PLA expresses excellent mechanical and moldability attributes nonetheless poor elasticity/functionality limits its widespread utilization. One approach to compensate for this is chemical surface modification through free radical grafting with small organic molecules like maleic anhydride (MA). The study undertakes the synthesis of succinic anhydride (SA)-grafted PLA [SA-g-PLA] films for sustained drug delivery applications. The entrapped porogen was leached out under alkaline treatment to make the PLA film porous by creating channels/cavities for drug inclusion. The success of the surface treatment of PLA-based films was investigated using specific chemical analyses. The results demonstrated the hydrophilic nature (water contact angle of 31°) of the SA-g-PLA films for the prevalence of MA (1780 cm