This work quantifies the relationship between the design tilt of an upstream rotor and the structural response of a spar floating offshore wind turbine located in its wake. Three wind speed scenarios are considered: below, at, and above rated operation. The inflow is generated with the Mann model and the wake and loads are simulated with FAST.Farm. As the upstream rotor tilt goes from 0� to 6�, we find that the mean wake is displaced upward by more than 0.2 rotor diameters (D) by a downstream distance of 7 D. The vertical velocities increase by up to 35 cm/s in the center of the wake. As a result, the downstream rotor is partially waked and experiences a rotated velocity vector. With a higher upstream rotor tilt, the velocities and moments on the downstream turbine increase their mean axial value and their lateral and vertical standard deviation. These changes affect the blade and tower loading and the floater motion primarily in the out-of-plane direction: the damage-equivalent loads for the tower pitch moment and blade-root moment increase by up to 10% because of higher variability at the first mode for the tower and at one blade passing frequency for the blade root. Lesser effects are observed for the roll moments and for floater sway and heave. When the joint effect of rotor tilt and platform motion is considered, the load response on the downstream system is amplified primarily for tower pitch and blade out-of-plane moment.