Wind resources far from the shore and in deeper seas have encouraged the offshore wind industry to look into floating platforms. The International Electrotechnical Commission (IEC) is developing a new technical specification for the design of floating offshore wind turbines that extends existing design standards for land-based and fixed-bottom offshore wind turbines. The work summarized in this paper supports the development of best practices and simulation requirements in the loads analysis of floating offshore wind turbines by examining the impact of wind/wave misalignment on the system loads under normal operation. Simulations of the OC3-Hywind floating offshore wind turbine system under a wide range of wind speeds, significant wave heights, peak-spectral periods and wind/wave misalignments have been carried out with the aero-servo-hydro-elastic tool FAST [4]. The extreme and fatigue loads have been calculated for all the simulations. The extreme and fatigue loading as a function of wind/wave misalignment have been represented as load roses and a directional binning sensitivity study has been carried out. This study focused on identifying the number and type of wind/wave misalignment simulations needed to accurately capture the extreme and fatigue loads of the system in all possible metocean conditions considered, and for a down-selected set identified as the generic US East Coast site. For this axisymmetric platform, perpendicular wind and waves play an important role in the support structure and including these cases in the design loads analysis can improve the estimation of extreme and fatigue loads. However, most structural locations see their highest extreme and fatigue loads with aligned wind and waves. These results are specific to the spar type platform, but it is expected that the results presented here will be similar to other floating platforms.