Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection in fetuses [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 572.8 Biochemical genetics
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2021
• Mô tả vật lý: Size: Article No. 100315 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259659
• Chủ đề: 1. 60 applied life sciences; 2. Biological science; 4. Et al; 5. Fetus; 6. Hiv-1; 7. Immune selection; 8. In utero transmission; 9. Mother to child transmission; 10. Mother-to-child transmission; 11. Signature

Tóm tắt

 Study of evolution and selection pressure on HIV-1 in fetuses will lead to a better understanding of the role of immune responses in shaping virus evolution and vertical transmission. Detailed genetic analyses of HIV-1 <
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  gene from 12 <
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  transmission pairs show that most infections (67%) occur within 2 months of childbirth. In addition, the <
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  sequences from long-term-infected fetuses are highly divergent and form separate phylogenetic lineages from their cognate maternal viruses. Host-selection sites unique to neonate viruses are identified in regions frequently targeted by neutralizing antibodies and T cell immune responses. Identification of unique selection sites in the <
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  gene of fetal viruses indicates that the immune system in fetuses is capable of exerting selection pressure on viral evolution. Studying selection and evolution of HIV-1 or other viruses in fetuses can be an alternative approach to investigate adaptive immunity in fetuses.