Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.9792 Other diseases
• Thông tin xuất bản: Bethesda, Md. : Oak Ridge, Tenn. : National Institutes of Health (U.S.) ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2021
• Mô tả vật lý: Size: p. 1528-1531 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259683
• Chủ đề: 1. 60 applied life sciences; 2. Hiv-1; 3. Replication-competent virus; 4. Reservoir; 5. T-cell activation

Tóm tắt

 Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. Here, we measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8<
 sup>
 +<
 /sup>
  T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.