SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.9 Other diseases
• Thông tin xuất bản: Argonne, Ill. : Oak Ridge, Tenn. : Argonne National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2021
• Mô tả vật lý: Size: Article No. e02940-20 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259760
• Chủ đề: 1. 60 applied life sciences; 2. Humoral immunity; 3. Infection severity; 4. Memory b cells; 5. Neutralizing antibodies; 6. Sars-cov-2

Tóm tắt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a global pandemic. The antigen specificity of the antibody response mounted against this novel virus is not understood in detail. Here, we report that subjects with a more severe SARS-CoV-2 infection exhibit a larger antibody response against the spike and nucleocapsid protein and epitope spreading to subdominant viral antigens, such as open reading frame 8 and nonstructural proteins. Subjects with a greater antibody response mounted a larger memory B cell response against the spike, but not the nucleocapsid protein. Additionally, we revealed that antibodies against the spike are still capable of binding the D614G spike mutant and cross-react with the SARS-CoV-1 receptor binding domain. Together, this study reveals that subjects with a more severe SARS-CoV-2 infection exhibit a greater overall antibody response to the spike and nucleocapsid protein and a larger memory B cell response against the spike.