Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 611.8 Nervous system Sense organs
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2020
• Mô tả vật lý: Size: p. 1085-1096 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259763
• Chủ đề: 1. 60 applied life sciences; 2. Alzheimer?sdisease; 3. Atrophy; 4. Cortical integrity; 5. Et al; 6. Flortaucipir; 7. Literature review; 8. Neurodegeneration; 9. Normal aging; 10. Part; 11. Pittsburgh compound b

Tóm tắt

Published reports of associations between ?-amyloid (A?) and cortical integrity conflict. Tau biomarkers may help elucidate the complex relationship between pathology and neurodegeneration in aging. We measured cortical thickness using magnetic resonance imaging, A? using Pittsburgh compound B positron emission tomography (PiB-PET), and tau using flortaucipir (FTP)-PET in 125 cognitively normal older adults. We examined relationships among PET measures, cortical thickness, and cognition. Cortical thickness was reduced in PiB+/FTP+ participants compared to the PiB+/FTP? and PiB?/FTP? groups. Continuous PiB associations with cortical thickness were weak but positive in FTP? participants and negative in FTP+. FTP strongly negatively predicted thickness regardless of PiB status. FTP was associated with memory and cortical thickness, and mediated the association of PiB with memory. Past findings linking A? and cortical thickness are likely weak due to opposing effects of A? on cortical thickness relative to tau burden. Tau, in contrast to A?, is strongly related to cortical thickness and memory.