Development of a New Chelation Model [electronic resource] : Bioassay Data Interpretation and Dose Assessment after Plutonium Intake via Wound and Treatment with DTPA

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Tác giả:

Ngôn ngữ: eng

Ký hiệu phân loại: 616.9 Other diseases

Thông tin xuất bản: Los Alamos, N.M. : Oak Ridge, Tenn. : Los Alamos National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2020

Mô tả vật lý: Size: p. 715-732 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 259775

 The administration of chelation therapy to treat significant intakes of actinides, such as plutonium, affects the actinide?s normal biokinetics. In particular, it enhances the actinide?s rate of excretion, such that the standard biokinetic models cannot be applied directly to the chelation-affected bioassay data in order to estimate the intake and assess the radiation dose. Here we propose a new chelation model that can be applied to the chelation-affected bioassay data after plutonium intake via wound and treatment with DTPA. In the proposed model, chelation is assumed to occur in the blood, liver, and parts of the skeleton. Ten datasets, consisting of measurements of <
 sup>
 14<
 /sup>
 C-DTPA, <
 sup>
 238<
 /sup>
 Pu, and <
 sup>
 239<
 /sup>
 Pu involving humans given radiolabeled DTPA and humans occupationally exposed to plutonium via wound and treated with chelation therapy, were used for model development. The combined dataset consisted of daily and cumulative excretion (urine and feces), wound counts, measurements of excised tissue, blood, and post-mortem tissue analyses of liver and skeleton. The combined data were simultaneously fit using the chelation model linked with a plutonium systemic model, which was linked to an ad hoc wound model. The proposed chelation model was used for dose assessment of the wound cases used in this study.
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