The impact of demographic, clinical, genetic, and imaging variables on tau PET status [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 610.73 Nursing and services of allied health personnel
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2020
• Mô tả vật lý: Size: p. 2245-2258 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259781
• Chủ đề: 1. 60 applied life sciences; 2. A?; 3. Alzheimer?s disease; 4. Dementia; 5. Mci; 6. Pet; 7. Tau

Tóm tắt

 Purpose: A substantial proportion of amyloid-? (A?)+ patients with clinically diagnosed Alzheimer?s disease (AD) dementia and mild cognitive impairment (MCI) are tau PET?negative, while some clinically diagnosed non-AD neurodegenerative disorder (non-AD) patients or cognitively unimpaired (CU) subjects are tau PET?positive. We investigated which demographic, clinical, genetic, and imaging variables contributed to tau PET status. Methods: We included 2338 participants (430 A?+ AD dementia, 381 A?+ MCI, 370 non-AD, and 1157 CU) who underwent [<
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 F]flortaucipir (<
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 n<
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  = 1944) or [<
 sup>
 18<
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 F]RO948 (<
 em>
 n<
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  = 719) PET. Tau PET positivity was determined in the entorhinal cortex, temporal meta-ROI, and Braak V-VI regions using previously established cutoffs. We performed bivariate binary logistic regression models with tau PET status (positive/negative) as dependent variable and age, sex,<
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 APOE<
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 ?4, A? status (only in CU and non-AD analyses), MMSE, global white matter hyperintensities (WMH), and AD-signature cortical thickness as predictors. Additionally, we performed multivariable binary logistic regression models to account for all other predictors in the same model. Results: Tau PET positivity in the temporal meta-ROI was 88.6% for AD dementia, 46.5% for MCI, 9.5% for non-AD, and 6.1% for CU. Among A?+ participants with AD dementia and MCI, lower age, MMSE score, and AD-signature cortical thickness showed the strongest associations with tau PET positivity. In non-AD and CU participants, presence of A? was the strongest predictor of a positive tau PET scan. Conclusion: We identified several demographic, clinical, and neurobiological factors that are important to explain the variance in tau PET retention observed across the AD pathological continuum, non-AD neurodegenerative disorders, and cognitively unimpaired persons.