Hitting the sweet spot [electronic resource] : exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.9792 Other diseases
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2020
• Mô tả vật lý: Size: p. 267-274 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259834
• Chủ đề: 1. 60 applied life sciences; 2. Biological science; 3. Broadly neutralizing antibodies, glycan shield, hiv-1 vaccines

Tóm tắt

The surface of the HIV-1 Env glycoprotein, the target of neutralizing antibodies, is extensively covered by N-linked glycans that create a glycan shield. Broadly neutralizing antibodies (bNAbs), the primary targets of HIV-1 vaccine design, have to negotiate this glycan shield. Here, we review the barriers and opportunities that the HIV-1 glycan shield presents for vaccine induction of bNAbs.