Investigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 548.7 Mathematical crystallography
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2019
• Mô tả vật lý: Size: Article No. 16960 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 259941
• Chủ đề: 1. 38 radiation chemistry, radiochemistry, and nuclear chemistry; 2. 59 basic biological sciences; 3. 60 applied life sciences; 4. Molecular medicine; 5. Nuclear chemistry; 6. Science & technology - other topics

Tóm tắt

 Astatine-211 is an attractive radionuclide for use in targeted alpha therapy of blood-borne diseases and micrometastatic diseases. Efficient isolation methods that can be adapted to robust automated <
 sup>
 211<
 /sup>
 At isolation systems are of high interest for improving the availability of <
 sup>
 211<
 /sup>
 At. Based on the early studies of Bochvarova and co-workers involving isolation of <
 sup>
 211<
 /sup>
 At from irradiated thorium targets, we developed a method for <
 sup>
 211<
 /sup>
 At isolation from bismuth targets using tellurium-packed columns. Dissolution of irradiated bismuth targets is accomplished using HNO<
 sub>
 3<
 /sub>
 
  however, <
 sup>
 211<
 /sup>
 At is not captured on the Te column material in this matrix. Our method involves slow addition of aqueous NH<
 sub>
 2<
 /sub>
 OH�HCl to the Bi target dissolved in HNO<
 sub>
 3<
 /sub>
  to convert to a HCl matrix. The amount of NH<
 sub>
 2<
 /sub>
 OH�HCl was optimized because (1) the quantity of NH<
 sub>
 2<
 /sub>
 OH�HCl used appears to affect the radiolabeling yield of phenethyl-<
 i>
 closo<
 /i>
 -decaborate(2-) (B10)-conjugated antibodies and (2) reducing the volume of NH<
 sub>
 2<
 /sub>
 OH�HCl solution can effectively shorten the overall isolation time. A proof-of-concept semi-automated process has been demonstrated using targets containing ~0.96 GBq (~26 mCi) of <
 sup>
 211<
 /sup>
 At. High isolation yields (88?95%) were obtained. Radiochemical purity of the isolated <
 sup>
 211<
 /sup>
 At was assessed by radio-HPLC. Concentrations of Bi and Te contaminants in the <
 sup>
 211<
 /sup>
 At and the astatinated antibodies were evaluated using ICP-MS.