Water dynamics in MCF-7 breast cancer cells [electronic resource] : a neutron scattering descriptive study

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Tác giả:

Ngôn ngữ: eng

Ký hiệu phân loại: 574.8 [Unassigned]

Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2019

Mô tả vật lý: Size: Article No. 8704 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 260019

Water mobility in cancer cells could be a powerful parameter to predict the progression or remission of tumors. In the present descriptive work, new insight into this concept was achieved by combining neutron scattering and thermal analyses. The results provide the frst step to untangle the role played by water dynamics in breast cancer cells (MCF-7) after treatment with a chemotherapy drug. By thermal analyses, the cells were probed as micrometric reservoirs of bulk-like and confned water populations. Under this perspective we showed that the drug clearly alters the properties of the confned water. We have independently validated this idea by accessing the cellular water dynamics using inelastic neutron scattering. Finally, analysis of the quasi-elastic neutron scattering data allows us to hypothesize that, in this particular cell line, difusion increases in the intracellular water in response to the action of the drug on the nanosecond timescale.
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