Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain [electronic resource]

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Tác giả:

Ngôn ngữ: eng

Ký hiệu phân loại: 616.831 *Alzheimer disease

Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2019

Mô tả vật lý: Size: Article No. 101848 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 260026

 According to the network model of neurodegeneration, the spread of pathogenic proteins occurs selectively along connected brain regions. We tested in vivo whether the distribution of filamentous tau (measured with [<
 sup>
 18<
 /sup>
 F]flortaucipir-PET), fibrillar amyloid-? ([<
 sup>
 11<
 /sup>
 C]PIB-PET) and glucose hypometabolism ([<
 sup>
 18<
 /sup>
 F]FDG-PET) follows the intrinsic functional organization of the healthy brain. We included 63 patients with Alzheimer's disease (AD
  30 male, 63 � 8 years) who underwent [<
 sup>
 18<
 /sup>
 F]flortaucipir, [<
 sup>
 11<
 /sup>
 C]PIB and [<
 sup>
 18<
 /sup>
 F]FDG PET, and 1000 young adults (427 male, 21 � 3 years) who underwent task-free fMRI. We selected six predefined disease epicenters as seeds for whole-brain voxelwise covariance analyses to compare correlated patterns of tracer uptake across AD patients against fMRI intrinsic connectivity patterns in young adults. We found a striking convergence between [18F]flortaucipir covariance patterns and intrinsic connectivity maps (range Spearman rho's: 0.32-0.78, p <
  .001), which corresponded with expected functional networks (range goodness-of-fit: 3.8-8.2). The topography of amyloid-? covariance patterns was more diffuse and less network-specific, while glucose hypometabolic patterns were more spatially restricted than tau but overlapped with functional networks. These findings suggest that the spatial patterns of tau and glucose hypometabolism observed in AD resemble the functional organization of the healthy brain, supporting the notion that tau pathology spreads through circumscribed brain networks and drives neurodegeneration.
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