Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 574.8 [Unassigned]
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2019
• Mô tả vật lý: Size: Article No. 38 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260027
• Chủ đề: 1. 60 applied life sciences; 2. Adjuvants; 3. Bicistronic; 4. Cytolytic; 5. Dna vaccine; 6. Hcv; 7. Hiv; 8. Perforin; 9. Plasmid; 10. Vaccine delivery

Tóm tắt

DNA vaccines present one of the most cost-effective platforms to develop global vaccines, which have been tested for nearly three decades in preclinical and clinical settings with some success in the clinic. However, one of the major challenges for the development of DNA vaccines is their poor immunogenicity in humans, which has led to refinements in DNA delivery, dosage in prime/boost regimens and the inclusion of adjuvants to enhance their immunogenicity. In this review, we focus on adjuvants that can enhance the immunogenicity of DNA encoded antigens and highlight the development of a novel cytolytic DNA platform encoding a truncated mouse perforin. The application of this innovative DNA technology has considerable potential in the development of effective vaccines.