Structural basis of ECF-?-factor-dependent transcription initiation [electronic resource]

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả:

Ngôn ngữ: eng

Ký hiệu phân loại: 612.3 Digestion

Thông tin xuất bản: Bethesda, Md. : Oak Ridge, Tenn. : National Institutes of Health (U.S.) ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2019

Mô tả vật lý: Size: Article No. 710 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 260066

 Extracytoplasmic (ECF) ? factors, the largest class of alternative ? factors, are related to primary ? factors, but have simpler structures, comprising only two of six conserved functional modules in primary ? factors: region 2 (?R2) and region 4 (?R4). Here, we report crystal structures of transcription initiation complexes containing Mycobacterium tuberculosis RNA polymerase (RNAP), <
 em>
 M. tuberculosis<
 /em>
  ECF ? factor ?L, and promoter DNA. The structures show that ?R2 and ?R4 of the ECF ? factor occupy the same sites on RNAP as in primary ? factors, show that the connector between ?R2 and ?R4 of the ECF ? factor?although shorter and unrelated in sequence?follows the same path through RNAP as in primary ? factors, and show that the ECF ? factor uses the same strategy to bind and unwind promoter DNA as primary ? factors. The results define protein-protein and protein-DNA interactions involved in ECF-?-factor-dependent transcription initiation.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 71010608 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH