L�vy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.6 Cell biology
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2018
• Mô tả vật lý: Size: Article No. 4539 (2018) : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260125
• Chủ đề: 1. 60 applied life sciences; 2. Bio-inspired; 3. Catalysis (homogeneous); 4. Charge transport; 5. Materials and chemistry by design; 6. Mesostructured materials; 7. Solar (photovoltaic); 8. Synthesis (novel materials); 9. Synthesis (self-assembly)

Tóm tắt

Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic cancer cells follow a qualitatively different movement strategy than their non-invasive counterparts. The trajectories of metastatic cells display clusters of small steps that are interspersed with long ?flights?. Such movements are characterized by heavy-tailed, truncated power law distributions of persistence times and are consistent with the L�vy walks that are also often employed by animal predators searching for scarce prey or food sources. In contrast, non-metastatic cancerous cells perform simple diffusive movements. These findings are supported by preliminary experiments with cancer cells migrating away from primary tumors in vivo. The use of chemical inhibitors targeting actin-binding proteins allows for ?reprogramming? the L�vy walks into either diffusive or ballistic movements.