Mathematical modeling of within-host Zika virus dynamics [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 610.6 Organizations, management, professions
• Thông tin xuất bản: Los Alamos, N.M. : Oak Ridge, Tenn. : Los Alamos National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2018
• Mô tả vật lý: Size: 81-96 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260170
• Chủ đề: 1. 60 applied life sciences; 2. 97 mathematics and computing; 3. Biological science

Tóm tắt

Recent Zika virus outbreaks have been associated with severe outcomes, especially during pregnancy. A great deal of effort has been put toward understanding this virus, particularly the immune mechanisms responsible for rapid viral control in the majority of infections. Identifying and understanding the key mechanisms of immune control will provide the foundation for the development of effective vaccines and antiviral therapy. In this paper, we outline a mathematical modeling approach for analyzing the within-host dynamics of Zika virus, and we describe how these models can be used to understand key aspects of the viral life cycle and to predict antiviral efficacy.