Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.9 Other diseases
• Thông tin xuất bản: Richland, Wash. : Oak Ridge, Tenn. : Pacific Northwest National Laboratory (U.S.) ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2018
• Mô tả vật lý: Size: Article No. 2 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260287
• Chủ đề: 1. 60 applied life sciences; 2. Anthrax; 3. Influenza; 4. Lung epithelial; 5. Nhbe

Tóm tắt

For over thirty years immortalized lung cells have enabled researchers to elucidate lung-pathogen molecular interactions. However, over the last five years numerous commercial companies are now providing affordable, ready-to-use primary lung cells for use in research laboratories. Despite advances in primary cell culture, studies using immortalized lung cells still dominate the recent scientific literature. In this paper, we highlight recent influenza and anthrax studies using in vitro primary lung tissue models and how these models are providing better predictive outcomes for when extrapolated to in vivo observations.