Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors [electronic resource] : 1950?2003

• Ngôn ngữ: eng
• Ký hiệu phân loại: 613.2 Dietetics
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2017
• Mô tả vật lý: Size: p. 17-29 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260316
• Chủ đề: 1. 60 applied life sciences; 2. 63 radiation, thermal, and other environ. pollutant effects on living orgs. and biol. mat; 3. Biophysics; 4. Environmental sciences & ecology; 5. Life sciences & biomedicine - other topics; 6. Radiology, nuclear medicine & medical imaging

Tóm tắt

The scientific community faces important discussions on the validity of the linear no-threshold (LNT) model for radiation-associated cardiovascular diseases at low and moderate doses. In the present study, mortalities from cerebrovascular diseases (CeVD) and heart diseases from the latest data on atomic bomb survivors were analyzed. The analysis was performed with several radio-biologically motivated linear and nonlinear dose?response models. For each detrimental health outcome one set of models was identified that all fitted the data about equally well. This set was used for multi-model inference (MMI), a statistical method of superposing different models to allow risk estimates to be based on several plausible dose?response models rather than just relying on a single model of choice. MMI provides a more accurate determination of the dose response and a more comprehensive characterization of uncertainties. It was found that for CeVD, the dose?response curve from MMI is located below the linear no-threshold model at low and medium doses (0?1.4 Gy). At higher doses MMI predicts a higher risk compared to the LNT model. A sublinear dose?response was also found for heart diseases (0?3 Gy). The analyses provide no conclusive answer to the question whether there is a radiation risk below 0.75 Gy for CeVD and 2.6 Gy for heart diseases. MMI suggests that the dose?response curves for CeVD and heart diseases in the Lifespan Study are sublinear at low and moderate doses. This has relevance for radiotherapy treatment planning and for international radiation protection practices in general.