Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 541 Physical chemistry
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2017
• Mô tả vật lý: Size: Article No. 16796 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260332
• Chủ đề: 1. 60 applied life sciences; 2. Science & technology - other topics

Tóm tắt

Chemotherapy is a primary treatment for the metastatic lung cancer patients. To select the most effective combination of drugs, we need an efficient way of assessing tumor response. Here, we showed that differential scanning calorimetry (DSC) analysis of blood serum proteins could reveal the patient response to the treatment. If chemotherapy is effective, serum proteins DSC curve of non-small cellular lung cancer (NSCLC) case is similar to the those of the healthy individuals. If treatment fails, notable changes occur in the DSC profile of NSCLC patient?s blood serum. Our preliminary work illustrates how thermal analysis of changes in the heat capacity of blood serum proteins can provide an insight into patient response to chemotherapy ? the essential information for any successive lung cancer treatment.