Nanocrystallography measurements of early stage synthetic malaria pigment [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 546 Inorganic chemistry
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2017
• Mô tả vật lý: Size: p. 1533-1540 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260366
• Chủ đề: 1. 36 materials science; 2. 59 basic biological sciences; 3. 60 applied life sciences; 4. Crystalline disorder; 5. Crystallography; 6. Crystalloraphy; 7. Malaria; 8. Serial femtosecond nanocrystallography; 9. Structural inhomogeniety

Tóm tắt

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 The recent availability of extremely intense, femtosecond X-ray free-electron laser (XFEL) sources has spurred the development of serial femtosecond nanocrystallography (SFX). Here, SFX is used to analyze nanoscale crystals of ?-hematin, the synthetic form of hemozoin which is a waste by-product of the malaria parasite. This analysis reveals significant differences in ?-hematin data collected during SFX and synchrotron crystallography experiments. To interpret these differences two possibilities are considered: structural differences between the nanocrystal and larger crystalline forms of ?-hematin, and radiation damage. Simulation studies show that structural inhomogeneity appears at present to provide a better fit to the experimental data. If confirmed, these observations will have implications for designing compounds that inhibit hemozoin formation and suggest that, for some systems at least, additional information may be gained by comparing structures obtained from nanocrystals and macroscopic crystals of the same molecule.<
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