Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 500 Natural sciences and mathematics
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2017
• Mô tả vật lý: Size: Article No. 38 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260633
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Botulinum; 4. Botulism; 5. Clostridium botulinum; 6. Et al; 7. Food science & technology; 8. Guidelines; 9. Neurotoxins; 10. Subtypes; 11. Toxicology

Tóm tắt

Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.