Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616 Diseases
• Thông tin xuất bản: Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2016
• Mô tả vật lý: Size: Article No. e0163619 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260655
• Chủ đề: 1. 60 applied life sciences; 2. Biomarkers; 3. Calcium channels; 4. Decision tree; 5. Electrocardiography; 6. Heart rate; 7. Ion channels; 8. Phase i clinical investigation; 9. Potassium channels

Tóm tắt

Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine and verapamil). Furthermore, identifying ECG signs of late sodium current block could aid in the determination of proarrhythmic risk for new drugs. A new cardiac safety paradigm for drug development (the "CiPA" initiative) will involve the preclinical assessment of multiple human cardiac ion channels and ECG biomarkers are needed to determine if there are unexpected ion channel effects in humans.