Vitamin E Circular Dichroism Studies [electronic resource] : Insights into Conformational Changes Induced by the Solvent?s Polarity

• Ngôn ngữ: eng
• Ký hiệu phân loại: 547.2 Organic chemical reactions formerly 547.139
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2016
• Mô tả vật lý: Size: Article No. 56 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260715
• Chủ đề: 1. ?-tocopherol; 3. 59 basic biological sciences; 4. 60 applied life sciences; 5. Circular dichroism; 6. Methylated tocopherol; 7. Reichardt?s dye; 8. Vitamin e

Tóm tắt

We used circular dichroism (CD) to study differences in CD spectra between ?-, ?-, and methylated-?-tocopherol in solvents with different polarities. CD spectra of the different tocopherol structures differ from each other in intensity and peak locations, which can be attributed to chromanol substitution and the ability to form hydrogen bonds. In addition, each structure was examined in different polarity solvents using the Reichardt index?a measure of the solvent?s ionizing ability, and a direct measurement of solvent?solute interactions. Differences across solvents indicate that hydrogen bonding is a key contributor to CD spectra at 200 nm. These results are a first step in examining the hydrogen bonding abilities of vitamin E in a lipid bilayer.