Impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.6 Cell biology
• Thông tin xuất bản: Beijing, China : Oak Ridge, Tenn. : National Natural Science Foundation of China (NSFC) ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2016
• Mô tả vật lý: Size: Article No. 31874 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260812
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Cd200-fc; 4. Lupus; 5. Lupus nephritis; 6. Nzbwf1

Tóm tắt

 Abnormal expression of CD200/CD200R1 may contribute to the immunologic abnormalities in patients with systemic lupus erythematosus (SLE). This study aimed to assess the function of CD200/CD200R1and impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice. Female NZB/WF1 mice were treated with CD200-Fc or control for 4 weeks. Plasma samples were collected to measure autoantibody levels. The expression levels of CD200/CD200R1 in peripheral blood mononuclear cells (PBMCs) and splenocytes were examined. The percentage of CD200/CD200R1-positive cells in splenocytes from NZB/WF1 mice was lower than that of C57BL/6 mice (p<
 0.05). The plasma level of anti-dsDNA was significantly higher in NZB/WF1 mice than C57BL/6 mice (p<
 0.001). However, the anti-dsDNA levels decreased (p=0.047) after CD200-Fc treatment. Finally, CD200-Fc reduced the levels of IL-6 (p=0.017) and IL-10 (p=0.03) in the dendritic cell culture supernatant. This study suggests that the immunosuppressive CD200/CD200R1 signaling pathway might be involved in the immunopathology of NZB/WF1 mice
  the present results merit further exploration of agents that can modulate the CD200/CD200FR1 pathway as a therapy for human lupus.