Augmenting drug?carrier compatibility improves tumour nanotherapy efficacy [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 574.5 [Unassigned]
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2016
• Mô tả vật lý: Size: Article No. 11221 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260863
• Chủ đề: 1. 60 applied life sciences; 2. 77 nanoscience and nanotechnology

Tóm tắt

 A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug?carrier association after intravenous administration is essential for efficient drug delivery to the tumour. However, a large number of currently available nanocarriers are self-assembled nanoparticles whose drug-loading stability is critically affected by the <
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  environment. Here we used in vivo FRET imaging to systematically investigate how drug?carrier compatibility affects drug release in a tumour mouse model. We found the drug?s hydrophobicity and miscibility with the nanoparticles are two independent key parameters that determine its accumulation in the tumour. Next, we applied these findings to improve chemotherapeutic delivery by augmenting the parent drug?s compatibility
  as a result, we achieved better antitumour efficacy. Lastly, our results help elucidate nanomedicines? in vivo fate and provide guidelines for efficient drug delivery.