PET Imaging of Tau Deposition in the Aging Human Brain [electronic resource]

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Tác giả:

Ngôn ngữ: eng

Ký hiệu phân loại: 616.8 Diseases of nervous system and mental disorders

Thông tin xuất bản: Berkeley, Calif. : Oak Ridge, Tenn. : Lawrence Berkeley National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2016

Mô tả vật lý: Size: p. 971-982 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 260905

 Tau pathology is a hallmark of Alzheimer?s disease (AD) but also occurs in normal cognitive aging. In this study, using the tau PET agent <
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 F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and ?-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical ?-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. In conclusion, the present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and ?-amyloid deposition.
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