Mathematics in modern immunology [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 611.018 Cytology and histology
• Thông tin xuất bản: Los Alamos, N.M. : Oak Ridge, Tenn. : Los Alamos National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2016
• Mô tả vật lý: Size: Article No. 20150093 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 260911
• Chủ đề: 1. 60 applied life sciences; 2. 97 mathematics and computing; 3. Diversity; 4. Immunology; 5. Mathematical modelling; 6. T cell; 7. T-cell receptor; 8. Two-photon microscopy

Tóm tắt

Mathematical and statistical methods enable multidisciplinary approaches that catalyse discovery. Together with experimental methods, they identify key hypotheses, define measurable observables and reconcile disparate results. Here, we collect a representative sample of studies in T-cell biology that illustrate the benefits of modelling?experimental collaborations and that have proven valuable or even groundbreaking. Furthermore, we conclude that it is possible to find excellent examples of synergy between mathematical modelling and experiment in immunology, which have brought significant insight that would not be available without these collaborations, but that much remains to be discovered.