Impact of lifestyle dimensions on brain pathology and cognition [electronic resource]

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Tác giả:

Ngôn ngữ: eng

Ký hiệu phân loại: 612.8 Nervous system Sensory functions

Thông tin xuất bản: Bethesda, Md. : Oak Ridge, Tenn. : National Institutes of Health (U.S.) ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2016

Mô tả vật lý: Size: p. 164-172 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 260964

Single lifestyle factors affect brain biomarkers and cognition. Here in this work, we addressed the covariance of various lifestyle elements and investigated their impact on positron emission tomography-based ?-amyloid (A?), hippocampal volume, and cognitive function in aged controls. Lower A? burden was associated with a lifestyle comprising high cognitive engagement and low vascular risk, particularly in apolipoprotein E ?4 carriers. Although cognitive function was related to high lifetime cognitive engagement and low vascular risk, A? load had no relation to current cognitive function. The covariance between high adult socioeconomic status, high education, and low smoking prevalence predicted better cognitive function and this was mediated by larger hippocampal volume. Our data show that lifestyle is a complex construct composed of associated variables, some of which reflect factors operating over the life span and others which may be developmental. These factors affect brain health via different pathways, which may reinforce one another. Finally, our findings moreover support the importance of an intellectually enriched lifestyle accompanied by vascular health on both cognition and presumed cerebral mediators of cognitive function.
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