Enzyme-activated intracellular drug delivery with tubule clay nanoformulation [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.8 Specific therapies and kinds of therapies
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2015
• Mô tả vật lý: Size: Article No. 10560 (2015) : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261143
• Chủ đề: 1. 60 applied life sciences

Tóm tắt

Fabrication of stimuli-triggered drug delivery vehicle is is an important milestone in treating cancer. Here we demonstrate the selective anticancer drug delivery into human cells with biocompatible 50-nm diameter halloysite nanotube carriers. Physically-adsorbed dextrin end stoppers secure the intercellular release of brilliant green. Drug-loaded nanotubes penetrate through the cellular membranes and their uptake efficiency depends on the cells growth rate. Intercellular glycosyl hydrolases-mediated decomposition of the dextrin tube-end stoppers triggers the release of the lumen-loaded brilliant green, which allowed for preferable elimination of human lung carcinoma cells (?549) as compared with hepatoma cells (Hep3b). In conclusion, the enzyme-activated intracellular delivery of brilliant green using dextrin-coated halloysite nanotubes is a promising platform for anticancer treatment.