Amyloid in dementia associated with familial FTLD [electronic resource] : not an innocent bystander

• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.8 Diseases of nervous system and mental disorders
• Thông tin xuất bản: Berkeley, Calif. : Oak Ridge, Tenn. : Lawrence Berkeley National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2015
• Mô tả vật lý: Size: p. 76-83 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261159
• Chủ đề: 1. 60 applied life sciences; 2. Alzheimer?s disease; 3. Amyloid; 4. Fdg-pet; 5. Frontotemporal dementia; 6. Mri

Tóm tắt

We present that patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case?control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Finally, our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer?s disease-like pattern of neurodegeneration.