Multirate delivery of multiple therapeutic agents from metal-organic frameworks [electronic resource]

• Ngôn ngữ: eng
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2014
• Mô tả vật lý: Size: 124108 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261284
• Chủ đề: 1. 36 materials science; 2. 60 applied life sciences; 3. Bacteria; 4. Drug delivery; 5. Materials properties; 6. Microstructured fibers; 7. Nickel

Tóm tắt

The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents?a biologically active gas, an antibiotic drug molecule, and an active metal ion?simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.