Cerenkov luminescence endoscopy [electronic resource] : Improved molecular sensitivity with ?--emitting radiotracers

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Ngôn ngữ: eng

Ký hiệu phân loại: 541 Physical chemistry

Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2014

Mô tả vật lý: Size: p. 1905-1909 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 261372

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Cerenkov luminescence endoscopy (CLE) is an optical technique that captures the Cerenkov photons emitted from highly energetic moving charged particles (?
+
or ?
$-$
) and can be used to monitor the distribution of many clinically available radioactive probes. A main limitation of CLE is its limited sensitivity to small concentrations of radiotracer, especially when used with a light guide. We investigated the improvement in the sensitivity of CLE brought about by using a ?
$-$
radiotracer that improved Cerenkov signal due to both higher ?-particle energy and lower ? noise in the imaging optics because of the lack of positron annihilation. Here, the signal-to-noise ratio (SNR) of 
90
Y was compared with that of 
18
F in both phantoms and small-animal tumor models. Sensitivity and noise characteristics were demonstrated using vials of activity both at the surface and beneath 1 cm of tissue. Rodent U87MG glioma xenograft models were imaged with radiotracers bound to arginine-glycine-aspartate (RGD) peptides to determine the SNR. As a result, ? noise from 
18
F was demonstrated by both an observed blurring across the field of view and a more pronounced fall-off with distance. A decreased ? background and increased energy of the ? particles resulted in a 207-fold improvement in the sensitivity of 
90
Y compared with 
18
F in phantoms. 
90
Y-bound RGD peptide produced a higher tumor-to-background SNR than 
18
F in a mouse model. In conclusion, the use of 
90
Y for Cerenkov endoscopic imaging enabled superior results compared with an 
18
F radiotracer.

1. ?-emitter
2. 60 applied life sciences
3. 62 radiology and nuclear medicine
4. Cerenkov luminescence endoscopy
5. Cerenkov luminescence imaging
6. Radionuclides

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Cerenkov luminescence endoscopy [electronic resource] : Improved molecular sensitivity with ?<sup>-</sup>-emitting radiotracers