Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 574 [Unassigned]
• Thông tin xuất bản: Oak Ridge, Tenn. : Oak Ridge, Tenn. : Oak Ridge National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2014
• Mô tả vật lý: Size: 2599-2606 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261378
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Autosampler; 4. Droplet-based liquid extraction; 5. Drug discovery; 6. Liquid microjunction; 7. Spatial distribution

Tóm tắt

 The aim of this paper was to evaluate the analytical performance of a fully automated droplet-based surface-sampling system for determining the distribution of the drugs acetaminophen and terfenadine, and their metabolites, in rat thin tissue sections. The following are the results: The rank order of acetaminophen concentration observed in tissues was stomach >
  small intestine >
  liver, while the concentrations of its glucuronide and sulfate metabolites were greatest in the liver and small intestine. Terfenadine was most concentrated in the liver and kidney, while its major metabolite, fexofenadine, was found in the liver and small intestine. In conclusion, the spatial distributions of both drugs and their respective metabolites observed in this work were consistent with previous studies using radiolabeled drugs.