The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 572.6 Proteins
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2015
• Mô tả vật lý: Size: p. 785-790 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261451
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Amyloid precursor protein; 4. Crystal structure; 5. Death receptor 6; 6. Dimerization; 7. Signal activation

Tóm tắt

The amyloid precursor protein (APP) has garnered considerable attention due to its genetic links to Alzheimer's disease. Death receptor 6 (DR6) was recently shown to bind APP via the protein extracellular regions, stimulate axonal pruning, and inhibit synapse formation. Here, we report the crystal structure of the DR6 ectodomain in complex with the E2 domain of APP and show that it supports a model for APP-induced dimerization and activation of cell surface DR6.