Effect of the amyloid ? hairpin's structure on the handedness of helices formed by its aggregates [electronic resource]

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Ngôn ngữ: eng

Ký hiệu phân loại: 636.7 Dogs

Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2013

Mô tả vật lý: Size: p. 2649-2655 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 261487

Various structural models for amyloid ? fibrils have been derived from a variety of experimental techniques. However, these models cannot differentiate between the relative position of the two arms of the ? hairpin called the stagger. Amyloid fibrils of various hierarchical levels form left-handed helices composed of ? sheets. However it is unclear if positive, negative and zero staggers all form the macroscopic left-handed helices. To address this issue we have conducted extensive molecular dynamics simulations of amyloid ? sheets of various staggers and shown that only negative staggers lead to the experimentally observed left-handed helices while positive staggers generate the incorrect right-handed helices. In conclusion, this result suggests that the negative staggers are physiologically relevant structure of the amyloid ? fibrils.
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