Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD [electronic resource]

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Tác giả:

Ngôn ngữ: eng

Ký hiệu phân loại: 616.2 Diseases of respiratory system

Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2010

Mô tả vật lý: Size: p. 1140-1147 : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 261631

 Asthma and COPD are characterized by airway dysfunction and infl ammation. Neutrophilic airway infl ammation is a common feature of COPD and is recognized in asthma, particularly in severe disease. The T helper (Th) 17 cytokines IL-17A and IL-17F have been implicated in the development of neutrophilic airway infl ammation, but their expression in asthma and COPD is uncertain. Methods: We assessed IL-17A and IL-17F expression in the bronchial submucosa from 30 subjects with asthma, 10 ex-smokers with mild to moderate COPD, and 27 nonsmoking and 14 smoking control subjects. Sputum IL-17 concentration was measured in 165 subjects with asthma and 27 with COPD. Results: The median (interquartile range) IL-17A cells/mm<
 sup>
 2<
 /sup>
  submucosa was increased in mild to moderate asthma (2.1 [2.4]) compared with healthy control subjects (0.4 [2.8]) but not in severe asthma (P = .04). In COPD, IL-17A<
 sup>
 +<
 /sup>
  cells/mm<
 sup>
 2<
 /sup>
  submucosa were increased (0.5 [3.7]) compared with nonsmoking control subjects (0 [0]) but not compared with smoking control subjects (P = .046). IL-17F<
 sup>
 +<
 /sup>
  cells/mm<
 sup>
 2<
 /sup>
  submucosa were increased in severe asthma (2.7 [3.6]) and mild to moderate asthma (1.6 [1.0]) compared with healthy controls subjects (0.7 [1.4]) (P = .001) but was not increased in subjects with COPD. IL-17A and IL-17F were not associated with increased neutrophilic inflammation, but IL-17F was correlated with the submucosal eosinophil count (rs = 0.5, P = .005). The sputum IL-17 concentration in COPD was increased compared with asthma (2 [0?7] pg/mL vs 0 [0?2] pg/mL, P <
  .0001) and was correlated with post-bronchodilator FEV<
 sub>
 1<
 /sub>
 % predicted (r = -0.5, P = .008) and FEV<
 sub>
 1<
 /sub>
 /FVC (r = -0.4, P = .04). Our findings support a potential role for the Th17 cytokines IL-17A and IL-17F in asthma and COPD, but do not demonstrate a relationship with neutrophilic inflammation
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