Platelet Proteome and Tumor Dormancy [electronic resource] : Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy?

• Ngôn ngữ: eng
• Ký hiệu phân loại: 576.8 Evolution
• Thông tin xuất bản: Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2010
• Mô tả vật lý: Size: p. 842-858 : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261650
• Chủ đề: 1. 59 basic biological sciences; 2. 60 applied life sciences; 3. Angiogenesis; 4. Early tumor detection; 5. Platelets; 6. Tumor dormancy

Tóm tắt

Although tumor dormancy is highly prevalent, the underling mechanisms are still mostly unknown. It is unclear which lesions will progress and become a disseminated cancer, and which will remain dormant and asymptomatic. Yet, an improved ability to predict progression would open the possibility of timely treatment and improvement in outcomes. We have recently described the ability of platelets to selectively uptake angiogenesis regulators very early in tumor growth, and proposed their use as an early marker of malignancy. In this review we will summarize current knowledge about these processes and will discuss the possibility of using platelet content to predict presence of occult tumors.