Compositions and methods related to serotonin 5-HT1A receptors [electronic resource]

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Tác giả:

Ngôn ngữ: eng

Ký hiệu phân loại: 615.722 Pharmacology and therapeutics

Thông tin xuất bản: Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2010

Mô tả vật lý: Medium: ED : , digital, PDF file.

Bộ sưu tập: Metadata

ID: 261670

 Contemplated substituted arylpiperazinyl compounds, and most preferably <
 sup>
 18<
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 F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with <
 sup>
 18<
 /sup>
 F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.
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