Favipiravir Flow Synthesis [electronic resource]

• Ngôn ngữ: eng
• Ký hiệu phân loại: 547.2 Organic chemical reactions formerly 547.139
• Thông tin xuất bản: Los Alamos, N.M. : Oak Ridge, Tenn. : Los Alamos National Laboratory ; Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2020
• Mô tả vật lý: Size: 4 p. : , digital, PDF file.
• Bộ sưu tập: Metadata
• ID: 261767
• Chủ đề: 1. 37 inorganic, organic, physical, and analytical chemistry; 2. 60 applied life sciences

Tóm tắt

Researchers at Los Alamos have invented a novel flow/batch chemistry synthetic process to produce the small molecule anti-viral favipiravir more cheaply and rapidly to enable on-demand production for pandemic response. Current methods for synthesizing favipiravir are constrained by long reaction times and low yields. If ongoing clinical trials for favipiravir demonstrate its effectiveness as a COVID-19 antiviral, and as a broad spectrum anti-viral for treating future viral outbreaks, this synthesis would help alleviate potential drug shortages and supply chain issues for the manufacturing and availability of this small molecule anti-viral. This U.S.-based synthesis route would be capable of scale-up for making large (kilogram) amounts of favipiravir as needed to assist with clinical trial needs and demand for patient treatment, and can also produce isotopically labeled favipiravir. We are seeking a CRADA partner to finalize method development who has interest in licensing the method and employing it for domestic production.